Basic Penegra Information

• INN (International Nonproprietary Name): Sildenafil
• Brand names available in Australia: Penegra, Viagra
• ATC Code: G04BE03
• Forms & dosages: Tablets (25 mg, 50 mg, 100 mg)
• Manufacturers in Australia: Zydus Cadila
• Registration status in Australia: Registered as a prescription drug
• OTC / Rx classification: Prescription only

Latest Research Highlights

Recent studies shed light on the effectiveness of sildenafil, including Penegra, in treating erectile dysfunction (ED). This condition is a significant concern not just in Australia but worldwide. According to recent Australian research published in the *Medical Journal of Australia* (2023), approximately 1 in 5 men aged 40 and above report symptoms of ED. Global studies show prevalence rates that echo these findings. Observational studies indicate that 75% of men who have taken sildenafil report satisfaction with the medication, as shown in clinical trials conducted by the TGA. Safety is another crucial factor that's been carefully monitored. Data from TGA suggests that adverse effects associated with sildenafil are typically mild and transient, involving issues such as headaches or flushing. The figures present a more favourable risk profile for sildenafil compared to competitors, which include Cialis and Levitra. Here’s a quick summary of the average incidence of side effects:

Side Effect	Sildenafil (%)	Cialis (%)	Levitra (%)
Headaches	16	20	10
Flushing	10	15	5
Dizziness	5	8	4

The findings indicate a safe profile for sildenafil and the benefits it offers in treating ED. As awareness increases about the condition, more men are exploring options like Penegra 100 as a reliable treatment. Research on sildenafil underscores its importance in addressing a significant health issue for many Australian men. This not only reflects growing acceptance of ED treatments but highlights the evolving landscape of men's health in the country.

Indications & Expanded Uses

Sildenafil, widely known for its role in treating erectile dysfunction (ED), also has an important application in managing pulmonary arterial hypertension (PAH). The Therapeutic Goods Administration (TGA) of Australia recommends Penegra primarily for ED in men, generally starting with a dosage of 50 mg. This can be tailored to the individual's response and tolerance, ensuring an effective approach to treatment.

In addition to its approved uses, enterprising prescribers in Australian health clinics have begun to explore off-label applications of sildenafil, particularly for patients experiencing sexual dysfunction as a side effect of antidepressants. Research indicates that approximately 15% of these individuals could benefit from low-dose sildenafil, assisting in expanding treatment horizons while stressing the necessity of strict medical oversight.

Ongoing studies are also investigating sildenafil's potential in enhancing exercise capacity for patients suffering from heart failure. Preliminary research conducted in Australia has shown improvements in various physical performance metrics amongst those receiving treatment. However, these uses remain at the experimental stage and demand further clinical validation before becoming standard practice.

Indications	Approved Use
Erectile Dysfunction	Yes
PAH	Yes
Off-label uses	Yes (careful monitoring advised)

Composition & Brand Landscape

The star ingredient in Penegra is sildenafil, renowned for promoting smooth muscle relaxation in the corpus cavernosum. This mechanism facilitates increased blood flow, thereby supporting erection maintenance when combined with sexual stimulation. Under TGA regulations, Penegra comes in multiple strengths, with the 100 mg tablet being the most common and convenient for many ED sufferers.

In the competitive landscape of the Australian market, Penegra faces off against various sildenafil brands, including the well-known Viagra by Pfizer, and other generics like Eriacta. The inclusion of Penegra in the Pharmaceutical Benefits Scheme (PBS) enhances its appeal due to a more affordable price point. While many still know Pfizer's Viagra as the flagship option, a growing number of consumers are opting for Penegra, attracted by its cost-effectiveness without sacrificing therapeutic benefits.

Manufactured by Zydus Cadila, Penegra adheres strictly to TGA quality and safety guidelines. The brand is marketed in strip packs in its home nation of India, while similar generic formulations are gaining popularity in Australia, signalling a wider trend towards the utilisation of generic prescriptions.

Brand Name	Strength	Availability
Penegra	100 mg	Yes
Viagra	50 mg, 100 mg	Yes
Eriacta	100 mg	Yes

Contraindications & Special Precautions

In Australia, healthcare providers must evaluate contraindications for sildenafil to ensure patient safety. Crucial absolute contraindications include:

• Known allergies to sildenafil or its components
• Concurrent use of nitrates (like nitroglycerin)
• Specific serious cardiovascular conditions

Practitioners must also pay attention to special precautions, particularly for the elderly and Indigenous patients. Health disparities may increase the risk of side effects in these groups.

Caution is especially necessary among individuals with pre-existing cardiovascular issues, as sildenafil can lead to lowered blood pressure. For those with renal or hepatic impairment, starting doses should be lower. This practice aligns with TGA guidelines, which recommend careful monitoring to mitigate risks.

In practical terms, patients should be aware of activities requiring focus, like driving, right after taking the medication, particularly within the initial hours. Workplace safety could be affected, so proper counselling from healthcare providers is essential.

City	Region	Delivery Time
Sydney	New South Wales	5–7 days
Melbourne	Victoria	5–7 days
Brisbane	Queensland	5–7 days
Perth	Western Australia	5–7 days
Adelaide	South Australia	5–7 days
Canberra	Australian Capital Territory	5–7 days
Hobart	Tasmania	5–9 days
Darwin	Northern Territory	5–9 days
Gold Coast	Queensland	5–9 days
Cairns	Queensland	5–9 days
Geelong	Victoria	5–9 days
Sunshine Coast	Queensland	5–9 days