Basic Dexilant Information

• International Nonproprietary Name (INN): Dexlansoprazole
• Brand names available in Australia: Dexilant
• ATC Code: A02BC06
• Forms & dosages: Capsules (30mg, 60mg)
• Manufacturers in Australia: Takeda Pharmaceuticals
• Registration status in Australia: Prescription only (Rx)

Latest Research Highlights

Recent studies indicate that dexlansoprazole has shown promise in managing gastroesophageal reflux disease (GERD) and erosive esophagitis.

A 2022 Australian study reported a significant improvement in symptom relief among patients using Dexilant as part of their treatment plan, matching international findings that highlight its efficacy.

Data from the Therapeutic Goods Administration (TGA) indicates a compliance rate of over 85% when dexlansoprazole is prescribed alongside patient education.

This evidence underpins the clinical use within Australia, with a focus on patient-centred outcomes. The dual delayed-release mechanism not only aids in symptom management but also reduces dependence on meal times for efficacy.

As healthcare professionals increasingly endorse its application, dexlansoprazole emerges as a key player in GERD management strategies throughout Australia.

Composition & Brand Landscape

The primary active ingredient in Dexilant is dexlansoprazole, a proton pump inhibitor (PPI), which is classified under the ATC code A02BC06. Dexilant is formulated as a dual delayed-release product, meaning it releases its active ingredient at two different times and locations within the gastrointestinal tract. This innovative design boosts its effectiveness in treating conditions such as gastroesophageal reflux disease (GERD) and erosive esophagitis.

In Australia, Dexilant is marketed with dosages presented in both 30mg and 60mg capsules, typically packaged in convenient blister packs. The Pharmaceutical Benefits Scheme (PBS) plays a pivotal role in making this medication accessible by providing financial support to eligible patients, thereby ensuring affordability.

Brand Availability

• Dexilant: Offered in 30mg and 60mg capsules.
• Generics: With the patent expiry, various generics are available in pharmacies throughout Australia, such as at Chemist Warehouse and Priceline. These alternatives help decrease medication costs, making treatment more affordable for patients.

When considering cultural context, Australians often favour established brands for their medications, especially those related to chronic conditions. The trust and familiarity of a brand such as Dexilant lead to its consistent use among patients. Additionally, the rise of online pharmacies and telehealth services offers increased convenience, enhancing accessibility for both urban and rural communities across the country.

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Contraindications & Special Precautions

Being aware of the contraindications for Dexilant is essential, especially in the context of Australian healthcare. Absolute contraindications include any hypersensitivity to dexlansoprazole or other PPIs, which can be particularly relevant in Indigenous populations due to potential genetic differences affecting drug metabolism. Additionally, combining Dexilant with medications containing rilpivirine poses a risk for severe interactions.

Relative contraindications also merit consideration, particularly:

• Elderly patients: They may demonstrate heightened sensitivity to side effects, necessitating careful monitoring.
• Pregnant women: Limited data concerning the drug’s safety underscores the need for thorough risk assessment before prescribing.
• Patients with osteoporosis: Long-term use of PPIs, including Dexilant, may harm calcium absorption and should be approached with caution.

Routine monitoring of magnesium and vitamin B12 is advised for individuals on long-term PPI therapy, as deficiencies can develop over time. Furthermore, Australian health authorities recommend a combined approach, suggesting lifestyle modifications alongside medication management.

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Dosage Guidelines

In Australia, Dexilant is typically prescribed based on the following standard guidelines:

• Adults with Erosive Esophagitis: 60mg once daily for up to 8 weeks to effectively heal the condition.
• Maintenance for Healed Erosive Esophagitis: 30mg once daily for a maximum of 6 months to prevent relapse.
• Symptomatic GERD Treatment: 30mg once daily for up to 4 weeks for symptom control.

Children aged 12 to 17 years are prescribed the same dosages as adults, as clinical evidence supports similar metabolic responses. Regular follow-ups every few weeks are recommended to monitor efficacy and side effects.

Dosage Adjustments: The Therapeutic Goods Administration (TGA) recommends no adjustments for mild to moderate hepatic impairment; however, Dexilant is not recommended for patients with severe hepatic impairment due to a lack of sufficient safety data. Elderly patients generally do not require dose adjustments but should be monitored closely for sensitivity.

In all cases, following dosing recommendations as per PBS guidelines is crucial for clinical success.

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Interactions Overview

Dexilant, known generically as dexlansoprazole, is primarily used for managing conditions like GERD and erosive esophagitis. While highly effective, there's a range of interactions that individuals in Australia must be aware of to ensure optimal treatment outcomes.

Food and Drink Conflicts

It's vital to consider how certain food and beverages might impact Dexilant's effectiveness.

• Alcohol: Although there's no documented interaction, taking Dexilant with alcohol can enhance gastrointestinal side effects, such as nausea and abdominal pain.
• Caffeine: High caffeine intake may raise stomach acidity levels, potentially undermining the benefits of the proton pump inhibitor (PPI).

Drug Interactions

Dexilant can interact with several medications, notably those dependent on a lower pH for absorption. Pay attention to the following:

• Atazanavir: This important HIV medication may lose its effectiveness if taken alongside Dexilant.
• Warfarin: Individuals on anticoagulants should be cautious, as combining with Dexilant can increase bleeding risks, necessitating regular monitoring of blood levels.

Reports from the Therapeutic Goods Administration (TGA) underscore the importance of comprehensive medication reviews. Such assessments help avoid polypharmacy issues. In rural areas, pharmacists play a crucial role in guiding patients through these interactions. This is especially vital, as access to healthcare may be limited, making it more important to consult local pharmacy guidelines on dexlansoprazole usage.

General Considerations

It's essential for patients to inform their healthcare providers about all medications, supplements, and over-the-counter drugs they are taking. This helps to mitigate risks associated with Dexilant drug interactions.

In Australia, Dexilant can be purchased without a prescription, making it accessible for many. However, the need for proper guidance cannot be overstated, especially when considering the various medications that might be affected.

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