Composition & Brand Landscape

Alfuzosin's main component is alfuzosin hydrochloride, a selective antagonist of the alpha-1 adrenergic receptors found in the prostate and bladder neck. This selective action is paramount for minimising unwanted systemic effects and boosts the drug's appeal among healthcare providers. Many patients experiencing benign prostatic hyperplasia (BPH) may find that alfuzosin offers effective relief without excessive side effects.

In Australia, alfuzosin is primarily marketed as Xatral®, readily available from prominent pharmacy chains such as Chemist Warehouse and Priceline. The most common formulation is the 10 mg extended-release tablet, crafted for consistent therapeutic effects with just a once-daily dose, accommodating the busy lives of patients.

Alfuzosin is listed on the PBS, which ensures subsidised access for eligible patients suffering from debilitating symptoms of BPH. This subsidy is essential for many Australians, as it helps alleviate the financial burden of managing chronic conditions.

Moreover, alfuzosin is often dispensed in its generic form, offering an economical treatment alternative while maintaining therapeutic equivalence. An amalgamation of brand credibility, PBS support, and broad pharmacy accessibility reinforces alfuzosin’s significant standing within the Australian pharmaceutical landscape.

Contraindications & Special Precautions

Certain groups should avoid alfuzosin due to significant contraindications. Individuals with severe renal impairment (eGFR < 30 mL/min/1.73m²), a condition notably affecting older adults, should be particularly cautious. It’s also not recommended for patients with severe hepatic impairment due to risks such as lactic acidosis.

In surgical settings, patients with a history of intraoperative floppy iris syndrome (IFIS) could encounter complications, notably during cataract surgeries. Those starting alfuzosin therapy should be advised about potential dizziness or hypotension, prompting caution with tasks like driving or heavy machinery operation.

Regular assessments for patients, particularly those over 65, are essential. Monitoring renal function and optimal dosing can prevent adverse events. Additionally, conducting thorough medication reviews for patients on multiple drugs can mitigate interaction risks, leading to safer management of BPH symptoms.

Dosage Guidelines

Adults diagnosed with BPH typically start with a standard dosage of 10 mg of alfuzosin, taken once daily after the same meal to facilitate absorption. Given individual responses and tolerance levels, healthcare providers should tailor treatment strategies accordingly, especially for the elderly or patients with renal issues.

Patients with renal impairment need careful monitoring and potential dosing adjustments based on eGFR levels. Regular communication with prescribers enhances treatment outcomes. After a few months on alfuzosin, practitioners should review therapy effectiveness and side effects with each patient, reinforcing the necessity of adherence and highlighting the importance of reporting any adverse effects or persistent symptomatology.

Interactions Overview

Worried about medication interactions? Alfuzosin, a common treatment for benign prostatic hyperplasia, can engage in various interactions that patients and providers need to keep an eye on.

Potential Drug Interactions

Alfuzosin may interact with several medications, which calls for a thorough medication history review by healthcare providers.

Here’s a spotlight on notable interactions:

• Antihypertensive medications: Using alfuzosin alongside other antihypertensive drugs may amplify hypotensive effects, increasing the risk of symptomatic hypotension.
• CYP3A4 inhibitors: The TGA cautions about combining alfuzosin with potent CYP3A4 inhibitors. This combination may elevate alfuzosin levels, raising the risk of side effects such as dizziness and drowsiness.

Food and Drink Considerations

Food and beverages can also affect alfuzosin's effectiveness. Notably:

• Grapefruit juice: It can increase the plasma concentration of alfuzosin, leading to intensified side effects. Therefore, it’s typically advised for patients to steer clear of grapefruit products while taking this medication.

Common Medication Interactions

Other medications often prescribed for various conditions should also be monitored closely when taking alfuzosin. For instance:

• Nasal decongestants
• Non-steroidal anti-inflammatory drugs (NSAIDs)

These interactions may not only complicate treatment but also heighten risks associated with drug interactions.

Patient Safety and Education

In Australia, healthcare professionals refer to the Scanlon Report, which catalogs these interactions. It aids in effectively managing drug interactions for patient safety. It's crucial for patients to understand the importance of adherence, dosing schedules, and the need to avoid specific foods or drinks.

Communication with healthcare providers can significantly help in avoiding complications. Patient education focused on these aspects can go a long way in mitigating risks associated with drug interactions.

Delivery Information for Alfuzosin

For those considering alfuzosin, it's accessible without a prescription from most pharmacies, ensuring a hassle-free experience. It's essential to consult a healthcare professional before making any changes to medication or treatment plans.